cnvCurator: an interactive visualization and editing tool for somatic copy number variations
نویسندگان
چکیده
منابع مشابه
Detection of germline and somatic copy number variations in cattle.
As a complement to the Bovine HapMap Consortium project, we initiated a systematic study of the copy numbervariation (CNV) within the same cattle population using array comparative genomic hybridization (array CGH). Oligonucleotide CGH arrays were designed and fabricated to cover all chromosomes with an average interval of 6 kb using the latest bovine genome assembly. In the initial screening, ...
متن کاملSeqeyes: A multi-scale interactive visualization tool for structural variations
Genomic structural variations are known to play an important role in cancer and other diseases. Next-generation sequencing is a key technology for the identification of such variations, but current data and algorithms yield many false positives and false negative predictions. We have created a prototype tool called Seqeyes to explore and interpret predicted structural variations to help guide e...
متن کاملOpenSoundEdit: An Interactive Visualization and Editing Framework for Timbral Resources
OpenSoundEdit is a sound-editing system that provides a unified three-dimensional user interface to edit complex sounds composed from different representations. Sounds are mapped onto a single three-dimensional space representing time, amplitude and a view-dependent third dimension (e.g., frequency, channel number, etc.) Sounds can be edited by direct manipulation on the 3D display window or us...
متن کاملaCNViewer: Comprehensive genome-wide visualization of absolute copy number and copy neutral variations
MOTIVATION Copy number variations (CNV) include net gains or losses of part or whole chromosomal regions. They differ from copy neutral loss of heterozygosity (cn-LOH) events which do not induce any net change in the copy number and are often associated with uniparental disomy. These phenomena have long been reported to be associated with diseases and particularly in cancer. Losses/gains of gen...
متن کاملHuman subtelomeric copy number variations.
Copy number variation is a defining characteristic of human subtelomeres. Human subtelomeric segmental duplication regions ('Subtelomeric Repeats') comprise about 25% of the most distal 500 kb and 80% of the most distal 100 kb in human DNA. Huge allelic disparities seen in subtelomeric DNA sequence content and organization are postulated to have an impact on the dosage of transcripts embedded w...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Bioinformatics
سال: 2015
ISSN: 1471-2105
DOI: 10.1186/s12859-015-0766-y